Journal: Materials Today Bio

Article Title: Fuel–maintenance coupling reprograms mitochondrial homeostasis to enable peripheral nerve regeneration

doi: 10.1016/j.mtbio.2026.103411

Figure Lengend Snippet: Immune microenvironment remodeling during peripheral nerve regeneration mediated by the LA-CS@Mag/PCL conduit. a) Schematic illustration of temporal immune modulation and peripheral nerve regeneration following implantation of the LA-CS@Mag/PCL nerve guidance conduit. b) Immunofluorescence staining of regenerated nerves at 1 week post-injury for iNOS and CD68, with c) quantitative analysis of iNOS levels. d) Immunohistochemical staining of regenerated nerves at 4 weeks post-injury for Arg1, CD163, and CD206, with quantitative analysis of e) Arg1, f) CD163, and g) CD206 levels. h) Immunofluorescence staining of regenerated nerves at 4 weeks post-injury for IL-6, with i) quantitative analysis of IL-6 levels. The data are expressed as mean ± SD (n = 3), ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001.

Article Snippet: Inflammatory responses were evaluated using antibodies against IL-6 (1:200, Abclonal), iNOS (1:500, Abclonal), CD68 (1:500), CD206 (1:1000), CD163 (1:2000), and Arg1 (1:500) (all from Proteintech unless noted).

Techniques: Immunofluorescence, Staining, Immunohistochemical staining